Session: 13-04-01: Applications of Micro and Nano Systems in Medicine and Biology

Paper Number: 142659

142659 - Robust Antimicrobial Surface With 3d Printing and Zno Nanoflowers 

In this study, we have developed an affordable and easily fabricated antimicrobial surface. Initially, a micropatterned 3D printed structure was created and then coated with zinc oxide (ZnO) nanoflowers. The micropatterned structure acted as a protective "armor" for the nanostructure against plastic scraping and finger abrasion. To evaluate the antimicrobial efficacy of the surface, the chip was submerged in an Escherichia coli (E. coli) suspension for 12, 24, and 48 hours at 37 °C. Results indicated that the micropatterned structure effectively trapped E. coli cells at their base. The ZnO nanoflowers exhibited significant inhibition of E. coli, reducing bacterial coverage by at least 20%. Abrasion tests demonstrated that the ZnO nanoflowers provided durable protection, outperforming flat surfaces or structures lacking ZnO nanoflower coating after 6 minutes. Additionally, it was observed that as abrasion time increased, ZnO nanoflowers were transferred to the ridge surface, while the percentage of bacterial coverage on the valley section increased but still remained superior to the control.

Presenting Author: Ke Du The University of California, Riverside

Presenting Author Biography: Dr. Ke Du is an assistant professor of chemical and environmental engineering at the University of California, Riverside and leads the Nanobiosensing, Nanomanufacturing, and Nanomaterials (3N) Lab. Additionally, He holds courtesy appointments in the department of bioengineering, materials science, and mechanical engineering.
Du’s research interests include in vitro molecular diagnostics, in vivo bioimaging, nanotoxicity, and nanomanufacturing. He is recipient of numerous awards and honors such as the EIPBN Best Journal Paper Award (2022), the NIH Maximizing Investigators’ Research Award (2021), the Burroughs Wellcome Fund (BWF) Collaborative Travel Grant (2019), and the James H. Potter Award for the outstanding Ph.D. students (2014).
He has been recognized as a global rising star in sensing by ACS Sensors and a finalist for the MINE 2020 Young Scientists Award. Du’s research has been supported by NIGMS, NIAID, NSF, USDA, DOE, BWF, the UNYTE Translational Research Network, and industry partners such as L3Harris, Mammoth Biosciences, Colgate Palmolive, and Biological Mimetics. He serves as an early career editorial advisory member for Biomicrofluidics (AIP Publishing) and Sensors and Actuators Reports (Elsevier).

Authors:

Henry Yuqing The University of California, Riverside
Shuhuan Zhang Rochester Institute of Technology
Ruonan Peng The University of California,Riverside
Blanca H. Lapizco-Encinas Rochester Institute of Technology
Rui Liu Rochester Institute of Technology
Ke Du The University of California, Riverside