Session: 13-06-01: Applied Mechanics and Materials in Micro- and Nano-Systems

Paper Number: 145015

145015 - Selective and Sensitive Determination of Dopamine in a Novel Gear Shaped Screen-Printed Electrode Modified With G-Pani Ink. 

Abstract:

Now-a-days electrochemical sensors are used to detect various analytes in bodily fluids. The electrodes of these sensors can be modified with various designs and particles. In our paper, we developed a novel gear-shaped electrode. The cyclic voltammetry (CV) analysis shows that the novel design has improved active surface area by 57% than without gear design. This novel design was fabricated as a screen-printed electrode using laser-induced graphene. Moreover, the novel shaped sensor was modified with polyaniline (G-PANI) ink to enhance the performance of the sensor. The physiochemical properties of the developed sensor were characterized using scanning electron microscopy (SEM) and X-ray diffraction (XRD). The modified electrode was used to detect dopamine (DA). Dopamine is an important catecholamines neurotransmitter which is known as “happy hormone”. It regulates various important body functions. But an abnormal range of dopamine in bodily fluid may lead to various diseases i.e., Parkinson disease, Alzheimer’s disease etc. This sensor can detect dopamine within the linear range of 0.1-10 µM, with a limit of detection (LOD) of 0.077µM (R2=0.98). Cyclic voltammetry, Electrical Impedance Spectroscopy (EIS) and chronoamperometry were also used to evaluate the performance of the sensor, in phosphate buffer saline (PBS) buffer with ferricyanide as the redox probe. The gear-shaped design has shown good repeatability and reproducibility. It has also shown a good selectivity in a ternary mixture of Uric Acid (UA) and Dopamine.

Presenting Author: Pritu Parna Sarkar The University of Texas Rio Grande Valley

Presenting Author Biography: Pritu Parna Sarkar is currently pursuing her masters in Biomedical Engineering at The University of Texas Rio Grande Valley. She is also working as a Graduate Research Assistant at UTRGV. She is doing her research in the effect of various shapes and designs of screen-printed electrode to detect different types of biomarkers.

Authors:

Pritu Parna Sarkar The University of Texas Rio Grande Valley
Ridma Tabassum The University of Texas Rio Grande Valley
Ahmed Jalal The University of Texas Rio Grande Valley
Ali Ashraf The University of Texas Rio Grande Valley
Nazmul Islam The University of Texas Rio Grande Valley