Session: Research Posters

Paper Number: 120215

120215 - Evaluation Methodology for Novel, Biocompatible, Inhomogeneous, and Advanced Materials: A Contextual Fusion Approach 

Susceptibility of biological tissue to natural phenomena like aging, disease, environmental conditions, nutrition, metabolism, and anomalies in excretory system, may cause the degradation of organs and possibly affect the wellbeing.   Absolute dependence on the traditional donor system may severely affect the treatment process due to the waiting time.  In addition, such a procedure may lead to the unethical practices.  Advancement of technology leads the transition to the manufacturing of tissue-engineered materials and organs.  The continuous refinement of tissue-engineered processes and systems require a means of customized evaluation.  This work discusses such means of evaluation procedures as appropriate to tissue engineered materials.  The work presents procedures for the evaluation of tissue-engineered materials by the selective use of destructive, minimum destructive and non-destructive procedures in order to obtain an optimally customized evaluation strategy.  The article presents the sample size evaluation procedures for the aforesaid nature of methods, while using the computational and experimental multi scale methods.  The practical concerns like inhomogeneity, deviation from the continuum assumption, and plasticity pose testing complexity and demands custom methods. The article includes discussion on testing the biodegradability of the materials used in specific tissue engineering processes.  The discussion includes the mode of application of the mechanical stress during the tissue engineering processes and its sufficiency for the application.  The article also presents scope for the customization of test methods developed for tissue-engineered materials and organs.  The article presents multi scale approach for the evaluation of tissue-engineered materials thus indicating the subtle use of the methodologies.  The eventual objective of the tissue-engineered processes and systems is to manufacture organs that gain the suitable biocompatibility with the beings. A discussion on the conceptual material that probably influences the senses and contributes to biocompatibility of tissue-engineered materials opens discussion on the refinement methods to follow while synthesizing the tissue.  Evaluation of the biocompatibility functions of the tissue engineered materials involve the testing of the reaction with the lively materials and processes.  A method of naturally powering the in-vivo bioreactor and testing its efficacy evaluates the concerned tissue engineering processes. The discussion includes the testing of the effectiveness of waste excretion in tissue engineering processes.  Testing for the possible generation of toxins in the life cycle of the tissue engineered constructs, materials, and organs involve the simulation methodology that encompasses the exposure to the various life processes.  Sufficiency requirements of the tests to evaluate the biocompatible features of tissue-engineered materials and organs conclude the article.

Presenting Author: Meghana Nidadavolu VHRVJIET

Presenting Author Biography: Student

Authors:

Satya Prasad Paruchuru VNR VJIET
Meghana Nidadavolu VHRVJIET